Download Autophagy at the Cell, Tissue and Organismal Level by Eleftherios Karanasios, Nicholas T. Ktistakis PDF

By Eleftherios Karanasios, Nicholas T. Ktistakis

ISBN-10: 3319331434

ISBN-13: 9783319331430

ISBN-10: 3319331450

ISBN-13: 9783319331454

This e-book presents a professional precis of autophagy, a comparatively new yet speedily increasing box of biomedical technology with vital implications in healthiness and ailment. After a ancient overview ranging as much as the id of autophagy genes in mammals, the authors talk about the signaling pathways that keep an eye on autophagy, the mechanism of autophagosome formation and the physiological roles of autophagy in improvement, growing older, neurodegeneration, immune functionality and phone differentiation. A entire checklist of beneficial antibodies for learning autophagy compiled as a neighborhood attempt is incorporated on the finish. The ebook is meant for newbies to the sphere, in addition to more matured researchers trying to find a condensed yet accomplished creation to the physiological functionality and law of the autophagic pathway in mammalian organisms.

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Additional info for Autophagy at the Cell, Tissue and Organismal Level

Example text

015 32 3 Signalling in Autophagy Jung CH, Seo M, Otto NM (2011) ULK1 inhibits the kinase activity of mTORC1 and cell proliferation. —PubMed—NCBI. FEBS J 282:4672–4678 Kaur J, Debnath J (2015) Autophagy at the crossroads of catabolism and anabolism. Nat Rev Mol Cell Biol 16:461–472. 1038/nrm4024 Kim J, Kim YC, Fang C et al (2013) Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell 152:290–303. 016 Kim J, Kundu M, Viollet B, Guan K-L (2011) AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.

79 Wirth M, Joachim J, Tooze SA (2013) Autophagosome formation—The role of ULK1 and Beclin1–PI3KC3 complexes in setting the stage. Semin Cancer Biol 23:301–309. —PubMed—NCBI. Sci 351:43–48. aab2674 Wong P-M, Puente C, Ganley IG, Jiang X (2013) The ULK1 complex: sensing nutrient signals for autophagy activation. Autophagy 9:124–137. 23323 Xiao J, Zhang T, Xu D et al (2015) FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation. Genes Dev 29:184–196.

Proc Natl Acad Sci USA 112: E6166–E6174. — PubMed—NCBI. Nat Rev Mol Cell Biol 1:11–21. — PubMed—NCBI. Autophagy in Mamm Syst Part B 452:181–197. 1016/S0076-6879(08) 03612-4 Burman C, Ktistakis NT (2010) Autophagosome formation in mammalian cells. Semin immunopathol 32:397–413. 1007/s00281-010-0222-z Cárdenas C, Miller RA, Smith I et al (2010) Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cell 142:270–283. 1016/j. 007 Cianfanelli V, De Zio D, Di Bartolomeo S et al (2015) Ambra1 at a glance.

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Autophagy at the Cell, Tissue and Organismal Level by Eleftherios Karanasios, Nicholas T. Ktistakis

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