By John C. Csernansky, John Lauriello
Showcasing the newest stories within the box, this reference unveils fresh breakthroughs within the use of strange antipsychotics for the therapy of various sufferer populations-tracking advancements within the administration of sufferers with schizophrenia and affective psychotic problems, in addition to healing regimens for kids and young people.
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Extra resources for Atypical Antipsychotics (Medical Psychiatry)
Naunyn Schmiedebergs Arch Pharmacol 1996; 353(3):290–294. 104. Kathmann M, Schlicker E, Gothert M. Intermediate affinity and potency of clozapine and low affinity of other neuroleptics and of antidepressants at H3 receptors. Psychopharmacology (Berl) 1994; 116(4):464–468. 105. Largent BL, et al. Novel antipsychotic drugs share high affinity for sigma receptors. Eur J Pharmacol 1988; 155(3):345–347. 106. Snyder SH, Largent BL. Receptor mechanisms in antipsychotic drug action: focus on sigma receptors.
Atypical antipsychotics 28 III. CONCLUSIONS The main conclusion of this review is that multiple pharmacological mechanisms are likely to contribute to the actions of atypical antipsychotic drugs (Table 7). Thus, although a balanced antagonism of 5-HT2A serotonin and D2-dopamine receptors provides a reliable template to produce “atypical” antipsychotic drugs, other targeting strategies are also Table 7 Classification of Atypical Antipsychotic Drugs Based on Pharmacological Mechanism 5-HT2A/D2 D2/D3 D2 partial agonist 5-HT2A inverse agonists Drug Risperidone; ziprasidone; olanzapine; quetiapine; clozapine Amisulpride; remoxipride Aripiprazole M100907; SR46349B Extrapyramidal side effects Varies from absent (clozapine; quetiapine) to high (risperidone) Moderately low Low to absent None Weight gain liabilities Varies from low (ziprasidone) to high (clozapine, olanzapine) Moderately low Low None Low Low Low/none Anticholinergic/orthostasis Varies likely to be successful.
Largent BL, et al. Novel antipsychotic drugs share high affinity for sigma receptors. Eur J Pharmacol 1988; 155(3):345–347. 106. Snyder SH, Largent BL. Receptor mechanisms in antipsychotic drug action: focus on sigma receptors. J Neuropsychiatry Clin Neurosci 1989; 1(1):7–15. 107. Schotte A, et al. Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. Psychopharmacology (Berl) 1996; 124(1–2):57– 73. 108. Gewirtz GR, et al. BMY 14802, a sigma receptor ligand for the treatment of schizophrenia.
Atypical Antipsychotics (Medical Psychiatry) by John C. Csernansky, John Lauriello