Download Annual Review of Immunology Volume 23 2005 by Annual Reviews PDF

By Annual Reviews

Show description

Read or Download Annual Review of Immunology Volume 23 2005 PDF

Similar immunology books

Encyclopedia of Medical Immunology: Autoimmune Diseases

The 4 quantity Encyclopedia of an infection and Immunity Vaccines covers all autoimmune, tropical, and infectious illnesses. It additionally areas emphasis on genetics, body structure, metabolism, pathogenesis and utilized microbiology.

Hematopathology. Morphology, Immunophenotype, Cytogenetics and Molecular Approaches

This finished, complete colour hematopathology reference e-book emphasizes immunophenotpic gains, cytogenetic experiences, and diagnostic molecular features. Hematopathology starts with introductions to morphologic overview of the hematopoietic tissues and rules of immunophenotyping, cytogenetics and molecular reviews through chapters devoted to sorts of hematologic issues.

Symposium in Immunology I and II

The Symposia in Immunology have been equipped to carry vital new details within the increasing box of immunology to practising physicians attracted to the sphere. hugely well known easy scientists percentage their effects with physicians undertaking medical study and thoses skilled within the therapy of the respective ailments.

RNA Vaccines: Methods and Protocols

This quantity presents an outline of the sphere and functional tricks for vaccinologists in academia and undefined. Chapters offer protocols on self-replicating RNA vectors, non-replication mRNA vectors, adjuvantation and supply, and preclinical and scientific improvement. Written within the hugely winning tools in Molecular Biology sequence structure, chapters comprise introductions to their respective issues, lists of the mandatory fabrics and reagents, step by step, quite simply reproducible laboratory protocols, and tips about troubleshooting and fending off recognized pitfalls.

Additional info for Annual Review of Immunology Volume 23 2005

Example text

In support of this idea, Myers et al. (223) found that anti-4-1BB stimulation of adoptively transferred CD8 T cells in the presence of Toll-receptor triggering (LPS) resulted in profound expansion of CD8 T cells, which in turn led to suppression of CD4 T cell proliferation by a TGF-β-dependent mechanism. Follow-up experiments also show that this effect is Ag-specific and IFN-γ -dependent (L. Myers & A. Vella, manuscript in preparation). The finding that anti-4-1BB can have apparently inhibitory or stimulatory effects depending on the disease and/or level of immune response means that one should exercise caution in applying anti-4-1BB therapeutically.

For personal use only. TNF FAMILY MEMBERS AS COSTIMULATORS 31 in vitro activation, declining again between 72 and 96 hr (104). Although CD28 is not essential for OX40 expression, engagement of CD28 can enhance the kinetics and level of OX40 expression on T cells (54, 105). OX40 is preferentially expressed on Th2 cells in some models (106, 107), but it can also be expressed on Th1 cells (104, 107, 108) and can play a role in both Th1 and Th2 responses (to be discussed below). In vivo, OX40-expressing CD4 T cells are found in close proximity to antigen-activated B cells in the spleen (107, 109).

Costimulatory effects of LIGHT on purified T cells are independent of CD28 signaling (246). Blocking of HVEM-LIGHT interaction using HSV-1 glycoprotein D, antiHVEM, or HVEM-Ig inhibits the proliferation of purified T cells responding to anti-CD3 or anti-CD3/CD28 (248–250). Furthermore, two studies showed that purified LIGHT–/– T cells have decreased responses to anti-CD3 alone, consistent with HVEM-LIGHT interactions during T-T interaction enhancing proliferation (251, 252). Although a third study did not show any defect in proliferation of LIGHT−/− T cells (253), this may reflect lower cell densities in the cultures leading to less efficient T-T contact.

Download PDF sample

Annual Review of Immunology Volume 23 2005 by Annual Reviews


by Robert
4.5

Rated 4.32 of 5 – based on 16 votes