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See Ref. 204, pp. 194– 203 48. Eisen HN, Reilly EB. 1985. Lambda chains and genes in inbred mice. Annu. Rev. Immunol. 3:337–65 49. Kawasaki K, Minoshima S, Nakato E, Shibuya K, Shintani A, Schmeits JL, Wang J, Shimizu N. 1997. One- RECEPTOR EDITING 50. 51. Annu. Rev. Immunol. 18:19-51. org by HINARI on 09/01/07. For personal use only. 52. 53. 54. 55. 56. 57. 58. 59. megabase sequence analysis of the human immunoglobulin lambda gene locus. Genome Res. 7:250–61 Stiernholm NBJ, Berinstein NL. 1994.

The hybridomas expressed endogenous L-chains that apparently altered B cell specificity and extinguished dsDNA binding. Suppression of dsDNA specificity was reversible in one hybridoma, when the endogenous j was lost, suggesting that binding of the transgenic H-chain with the endogenous L-chain outcompeted transgenic L-chain. In addition to this evidence for ‘‘phenotypic’’ allelic exclusion, among these hybrids an excessive use of endogenous Vj12/13 genes associated with downstream Jjs was observed.

Exp. Med. 168:2131–37 Begley CG, Aplan PD, Davey MP, de Villartay JP, Cohen DI, Waldmann TA, Kirsch IR. 1989. Demonstration of delta rec-pseudo J alpha rearrangement with deletion of the delta locus in a human stem-cell leukemia. J. Exp. Med. 170:339–42 Hockett RD, de Villartay JP, Pollock K, Poplack DG, Cohen DI, Korsmeyer SJ. 1988. Human T-cell antigen receptor (TCR) delta-chain locus and elements responsible for its deletion are within the TCR alpha-chain locus. Proc. Natl. Acad. Sci. USA 85:9694–98 Verschuren MC, Wolvers-Tettero IL, Breit TM, Noordzij J, van Wering ER, van Dongen JJ.

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