Download Animals in Scientific Research: An Effective Substitute for by P. Turner PDF

By P. Turner

ISBN-10: 1349064394

ISBN-13: 9781349064397

ISBN-10: 1349064416

ISBN-13: 9781349064410

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Extra resources for Animals in Scientific Research: An Effective Substitute for Man?: Proceedings of a Symposium held in April 1982 under the auspices of the Humane Research Trust

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Each test would be used to monitor the ability of the test substance to trigger a particular initiating event. Largely qualitative results would be appropriate. A number of false positive results would be accept- 49 Association with other substances present t / across cell membrane ---7Substance~Passage 1, pH

Such tests involve the use of large numbers of animals particularly when looking for small effects at doses which are comparable to human exposure levels. Long-term genetic damage which may give rise to congenital abnormalities may be assayed by the use of specialised strains of mice exposed to test chemicals and the damage produced determined in their progeny. Such assays may be designed to provide information which is of direct relevance to potential human exposure. Examples of such assays are the specific locus test.

The procedure for the measurement of dominant lethal mutations produced by a potential chemical mutagen involves the treatment of sexually mature mice (8 to 10 weeks old) of proven fertility with the test agent by a variety of routes of administration. Treated and untreated males are mated with virgin females over a number of weeks to allow for the sampling of a variety of stages in sperm development. The females are killed 17 days after mating and, after dissection the contents of the uterus, are examined for the presence of normal and abnormal fetuses and defective implantations.

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Animals in Scientific Research: An Effective Substitute for Man?: Proceedings of a Symposium held in April 1982 under the auspices of the Humane Research Trust by P. Turner


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