Download Amphioxus immunity : tracing the origins of human immunity by An-Long Xu PDF

By An-Long Xu

ISBN-10: 0128096470

ISBN-13: 9780128096475

ISBN-10: 0128499036

ISBN-13: 9780128499030

Amphioxus Immunity: Tracing the foundation of Human Immunity covers a notable diversity of data approximately Amphioxus and its evolutionary context. This compilation of what's presently identified approximately Amphioxus, with a pointy specialize in its immune method, contains thirteen issues, such as:

  • Amphioxus as a version for knowing the evolution of vertebrates
  • basic wisdom of immunology
  • immune organs and cells of amphioxus
  • a genomic and transcriptomic view of the Amphioxus immunity
  • pattern reputation approach in Amphioxus
  • transcription components in Amphioxus
  • the supplement method of Amphioxus
  • the oxidative burst approach in Amphioxus
  • immune effectors in Amphioxus
  • lipid signaling of immune reaction in Amphioxus
  • apoptosis in amphioxus; primitive adaptive immune process of Amphioxus
  • and destiny learn directions

This useful reference ebook is loaded with info that might be important for someone who needs to profit extra concerning the starting place of vertebrates and adaptive immunity.

  • Provides new facts at the beginning of the adaptive immune process, the evolution of innate immunity, and evolution-stage particular immune safety mechanisms
  • Not merely provides the cells and molecules taken with the adaptive immune reaction in Amphioxus, but in addition characterizes the origination and evolution of the gene households and pathways curious about innate immunity
  • Includes a lot pioneering paintings, from the molecular, genomic, and mobile to the person level

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2011). , 2007). Thus, RLR signaling pathways are important antiviral defense mechanisms and are elaborately designed and strictly regulated in the host. 4 C-type lectins C-type lectins represent a large family of proteins with Ca2+-dependent carbohydratebinding ability. All the members of this family share at least one or more C-type lectin (-like) domain(s) (CTLD), which is a compact structural module that contains a conserved residual motif and determines the carbohydrate specificity of the C-type lectin receptors (CLRs).

4). 4 RIG-I-like, Receptor-Mediated Signaling Pathway. RIG and MDA5 can both recognize the RNA virus with their helicase domains, then recruit IPS-1, and eventually activate the IRF3, IRF7, and NF-kB transcription factors. , 2011). , 2007). Thus, RLR signaling pathways are important antiviral defense mechanisms and are elaborately designed and strictly regulated in the host. 4 C-type lectins C-type lectins represent a large family of proteins with Ca2+-dependent carbohydratebinding ability. All the members of this family share at least one or more C-type lectin (-like) domain(s) (CTLD), which is a compact structural module that contains a conserved residual motif and determines the carbohydrate specificity of the C-type lectin receptors (CLRs).

In contrast to dectin-1, dectin-2 lacks a recognized signaling motif in the cytoplasmic region, but it can mediate a downstream signaling pathway through an interaction with the Fc receptorg (FcRg), which contains an immunoreceptor tyrosine-based activation motif (ITAM) and can link the Src kinase with dectin-2, which eventually leads to the activation of NF-kB, and the production of TNF-a and the IL-1 receptor antagonist. , 2010). Although some CLRs might share some components in signaling pathways, mostly they use unique combination with distinct components.

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Amphioxus immunity : tracing the origins of human immunity by An-Long Xu


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