Download AIDS-Associated Viral Oncogenesis (Cancer Treatment and by Craig Meyers PDF

By Craig Meyers

ISBN-10: 0387468048

ISBN-13: 9780387468044

ISBN-10: 0387468161

ISBN-13: 9780387468167

One of crucial points of AIDS is the lack of protecting immune functionality within the contaminated host which results in elevated occurrence of opportunistic infections and cancers. This publication particularly addresses viral-induced human cancers linked to AIDS and saw within the AIDS inhabitants. It addresses the categorical therapy required during this precise inhabitants and the molecular biology of the causative viral agents.

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Extra resources for AIDS-Associated Viral Oncogenesis (Cancer Treatment and Research)

Sample text

247 in this study that oral etoposide may be a safe, tolerable, and active agent in MCD. In a retrospective study by Loi and colleagues,242 11 patients, ten of whom were already on HAART prior to chemotherapy, were treated mostly with cyclophosphamide and chorambucil, combined with prednisolone. 2 months. Mortality from MCD and its resulting complications was 45% in this series. Steroids are generally used along with chemotherapy, thus results are limited in treatment for MCD. 226 42 AIDS-Associated Viral Oncogenesis Antiviral Therapy Inconsistent results have been reported in various studies from the use of antiviral therapy targeting HHV-8.

004). 001). 012). In addition,The Swiss cohort study76 with 6,636 HIV-infected individuals found the incidence of systemic NHL post-HAART to be 4 cases/1,000 p-y. 2. AIDS Malignancies 29 However, other studies found nonsignificant increases in AIDS-related NHL incidence. 2). 5 cases/1,000 p-y post-HAART (p-value not significant). 86,87 The IPI includes clinical features that reflect the growth and invasive potential of the tumor (tumor stage, serum LDH level, and number of extranodal disease sites), the patient’s response to the tumor (performance status), and the patient’s ability to tolerate Table 3.

027). Up to 60% of deaths were in patients with a CD4 count of <50/mm3, and 40% occurred during the maintenance phase of rituximab. 101–104 More recently, several authors have reported on small series of patients treated at individual institutions for high-first risk remission, relapsed, or refractory ARL. No definitive conclusions regarding efficacy can be made due to the small and varied group of patients. 79 All studies except the French series by Diez-Martin108 and colleagues have required HIV disease to be under control for HCT, either by low to undetectable HIV viral loads or CD4 counts >100/mm3.

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AIDS-Associated Viral Oncogenesis (Cancer Treatment and Research) by Craig Meyers


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