Download Advances in Nanotheranostics I: Design and Fabrication of by Zhifei Dai PDF

By Zhifei Dai

ISBN-10: 3662485427

ISBN-13: 9783662485422

ISBN-10: 3662485443

ISBN-13: 9783662485446

This ebook highlights the hot advances in nanotheranostics from simple study to capability functions, and discusses the modular layout and engineering of multiplex nanoparticles together with gold nanostructures, luminescent nanoparticles, dendrimers and liposomes. every one bankruptcy demonstrates multifunctional nanoparticles with themes masking concentrating on, imaging, supply, diagnostics, and treatment as new modalities for melanoma theranostics. This accomplished publication provides professional perspectives at the most recent advancements in theranostic nanomedicine.

It makes a speciality of strength theranostic functions of multifunctional nanoparticles starting from deciding on noninvasively melanoma cells via molecular detection, and visualizing in vivo drug supply via distinction more advantageous imaging, to destroying melanoma mobilephone s with minimum unwanted side effects through selective accumulation at tumor websites, and real-time tracking healing effectiveness. It additionally offers an interdisciplinary survey of nanotheranostics and as such is a important source for researchers and scholars in comparable fields.

Zhifei Dai is a Professor on the division of Biomedical Engineering, collage of Engineering, Peking college, China.

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Additional info for Advances in Nanotheranostics I: Design and Fabrication of Theranosic Nanoparticles

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Histological analysis of excised tumor tissue showed that CET-AuNRs-treated tumors exhibited severe cellular damage compared to the nontreated control after NIR laser irradiation. Recently, imaging-guided dual modal cancer treatment has been developed to improve the therapy efficacy. For instance, Kuo et al. designed a fluorescent AuNRs conjugate to simultaneously serve as photodynamic therapy (PDT) and hyperthermia agents [144]. The conjugate was prepared by coating AuNRs with poly (styrenealt-maleic acid) (PSMA) and ICG, a hydrophilic and anionic photosensitizer in sequence via electrostatic interaction.

The former was found to be internalized into KB cells within hours, while the latter was accumulated on the cell surface over the same time interval [141]. Black et al. conjugated AuNRs with deltorphin, a high-affinity ligand for delta opioid receptor (δOR) which expressed on human colon carcinoma HCT-116 cell line. Selective imaging and photothermal ablation were observed in receptor-expressing cells while not in cells that did not express the receptor in a mixed population of cells [119]. By conjugation AuNRs with a NIR fluorescent dye through a peptide linker, which could be degraded by matrix metalloprotease (MMP), Yi et al.

188]. ) 1 Near-Infrared Light-Mediated Gold Nanoplatforms for Cancer Theranostics 37 and invasion in vitro and in vivo (Fig. 14). For breast cancer cells (MDA-MB-231) treated with AuNRs or not, both stable isotope labeling by amino acids in cell culture (SILAC)-based proteomics analysis and real-time PCR array have been used to study the protein and mRNA expression. They found that exposure of cells to AuNRs can downregulate the expression of diverse energy generation-related genes, which is due to the inhibitory effects of AuNRs on mitochondrial oxidative phosphorylation (OXPHOS) and glycolysis.

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