Download Adoptive immunotherapy : methods and protocols by Burkhard Ludewig, Matthias W. Hoffmann PDF

By Burkhard Ludewig, Matthias W. Hoffmann

ISBN-10: 1588294064

ISBN-13: 9781588294067

ISBN-10: 1592598625

ISBN-13: 9781592598625

An authoritative selection of optimum strategies for generating and characterizing the immunologically energetic cells and effector molecules now gaining broad use within the scientific remedy of sufferers. making the most of the most recent applied sciences, the authors current easily reproducible experimental protocols for the learn of dendritic cells, T cells, monoclonal antibodies, and bone marrow transplantation. The emphasis is on preclinicical and medical purposes and at the development of chosen methods in scientific trials. extra chapters disguise the molecular definition of goal antigens, mathematical modeling ways to immunotherapy, and the usage of regulatory T cells. The protocols give the chance to review the adoptive move of adapted antigen-specific immune cells and to enhance the medical program of adoptive immunotherapy.

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Extra resources for Adoptive immunotherapy : methods and protocols

Example text

Berger, T. , et al. (2002) Rapid induction of tumorspecific type 1 T helper cells in metastatic melanoma patients by vaccination with mature, cryopreserved, peptide-loaded monocyte-derived dendritic cells. J. Exp. Med. 195, 1279– 1288. 78. , et al. (2000) Regression of human metastatic renal cell carcinoma after vaccination with tumor cell–dendritic cell hybrids. Nat. Med. 6, 332–336. 79. 79 Timmerman, J. , Czerwinski, D. , Davis, T. , et al. (2002) Idiotype-pulsed dendritic cell vaccination for B-cell lymphoma: clinical and immune responses in 35 patients.

Immunol. Meth. 196, 137–151. 98. , et al. (1997) Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. Eur. J. Immunol. 27, 3135–3142. 16 O’Neill and Bhardwaj 99. , et al. (2002) A clinical grade cocktail of cytokines and PGE(2) results in uniform maturation of human monocyte-derived dendritic cells: implications for immunotherapy. Vaccine 20(Suppl. 4), A8–A22. 100. , and Groettrup, M. (2002) Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells.

68 Ashley, D. , Hale, L. , Bigner, D. , and Gilboa, E. (1997) Bone marrow-generated dendritic cells pulsed with tumor extracts or tumor RNA induce antitumor immunity against central nervous system tumors. J. Exp. Med. 186, 1177–1182. 69. 69 Celluzzi, C. M. and Falo, L. , Jr. (1998) Physical interaction between dendritic cells and tumor cells results in an immunogen that induces protective and therapeutic tumor rejection. J. Immunol. 160, 3081–3085. 70. , Nair, S. , and Lyerly, H. K. (1998) Immunotherapy of cancer with dendriticcell-based vaccines.

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Adoptive immunotherapy : methods and protocols by Burkhard Ludewig, Matthias W. Hoffmann

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